In Wrath of the Titans, which the story takes place during the decade after the incident that occurred at the Clash of the Titans, Perseus (Sam Worthington) is now living as a fisherman with his son, Helius (John Bell), after his wife died Io. One day, Perseus is visited by his father, Zeus (Liam Neeson), who asked for help Perseus to return to lead the troops to secure the power of the gods of some of the threats that come because of their power waning as more and more people who reject god. Perseus, who did not want to risk that with its participation in the war would make his son had to grow their own, then rejected the request of Zeus.
The threat itself then became evident when Zeus betrayed by his son, Ares (Edgar Ramirez), in collaboration with sibling Zeus, Hades (Ralph Fiennes), to seize its power to revive the father's power of Zeus and Hades, Kronos. Poseidon (Danny Huston), who was seriously injured because of an attack Ares and Hades, telling the news to Perseus and asked him to rescue Zeus. On the advice of Poseidon, Perseus finally went to see Queen Andromeda (Rosamund Pike) and the son of Poseidon, Agenor (Toby Kebbell), which can help to meet Hephaestus (Bill Nighy), which then can show them the way to the place where Zeus imprisoned Ares and Hades.